Muscle relaxant less sedating


12-May-2016 04:42

The usual dose is 5–10mg three times daily and treatment for more than 2–3 weeks is not recommended.Side effects are common, at least one occurring in 53% of patients, and are similar to those observed with TCAs.Common side effects include dysgeusia, constipation, dyspepsia, nausea, xerostomia, confusion, dizziness, headache, somnolence, blurred vision and nervousness.Particular care should be exercised in the elderly where is structurally related to tricyclic anti-depressants and thus causes sedation through its anticholinergic effects.One report suggested that coadministration with pro-serotonergic agents such as selective serotonin reuptake inhibitors (SSRIs) may predispose patients to life-threatening serotonin syndrome.with monoamine oxidase inhibitors or use within 14 days after their discontinuation is contraindicated.

The drug should, therefore, be used with caution in individuals with angle-closure glaucoma or prostatic hypertrophy.As with other TCAs, may interact with monoamine oxidase inhibitors and should not be used concurrently or within 14 days of discontinuation of these drugs.



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